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Symbol
Name
ID 		Trp53
transformation related protein 53
MGI:98834
Phenotype annotations related to endocrine/exocrine glands
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Diabetes mellitus
Type II diabetes mellitus
Exocrine pancreatic insufficiency
Neoplasm of the pancreas
Pancreatic adenocarcinoma
Increased circulating free T3
Increased circulating free T4 concentration
Decreased thyroid-stimulating hormone level
Adrenocortical carcinoma
Goiter
Thyroid carcinoma
Non-medullary thyroid carcinoma
Papillary thyroid carcinoma
Graves disease
Disease(s) Associated with TP53
coronary artery disease
Graves' disease
Li-Fraumeni syndrome
Li-Fraumeni syndrome 1
pancreatic cancer
thyroid gland papillary carcinoma

Mouse Phenotypes
abnormal thymocyte apoptosis
decreased thymocyte apoptosis
increased thymocyte apoptosis
endocrine/exocrine gland phenotype
abnormal thymus morphology
increased thymus weight
small thymus
abnormal mammary gland development
abnormal mammary gland growth during lactation
increased mammary gland tumor incidence
increased mammary adenocarcinoma incidence
ovary cyst
ovary degeneration
decreased testis weight
small testis
testis hypoplasia
increased ovary tumor incidence
increased pancreas tumor incidence
increased testis tumor incidence
increased testicular teratoma incidence
increased T cell derived lymphoma incidence
abnormal thymus physiology
abnormal mammary gland physiology
lactation failure
Availability Mouse Genotype
Gt(ROSA)26Sortm1.1(CAG-Trp53*,-EGFP)Medz/Gt(ROSA)26Sortm1.1(CAG-Trp53*,-EGFP)Medz
Trp53tm1.1Manf/Trp53tm1.1Manf
Trp53tm1.1Thst/Trp53tm1.1Thst
Trp53tm1.1Tldo/Trp53tm1.1Tldo
Trp53tm1.1Umol/Trp53tm1.1Umol
Trp53tm1.1Wgu/Trp53tm1.1Wgu
Trp53tm1.2Awbr/Trp53tm1.2Awbr
Trp53tm1Brd/Trp53tm1Brd
Trp53tm1Gev/Trp53tm1Gev
Trp53tm1Glo/Trp53tm1Glo
Trp53tm1Sia/Trp53tm1Sia
Trp53tm1Thst/Trp53tm1Thst
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Trp53)1Srn/0
Trp53tm1Tyj/Trp53tm1Tyj
Trp53tm1Xu/Trp53tm1Xu
Trp53tm2.1Snj/Trp53tm2.1Snj
Trp53tm2.1Thst/Trp53tm2.1Thst
Trp53tm2.1Umol/Trp53tm2.1Umol
Trp53tm2.1Wgu/Trp53tm2.1Wgu
Trp53tm4Glo/Trp53tm4Glo
Trp53tm4Xu/Trp53tm4Xu
Trp53tm7.1Xu/Trp53tm7.1Xu
Trp53Bbl/Trp53+
Trp53bhy/Trp53+
Trp53tm1.2Awbr/Trp53+
Trp53tm1Brd/Trp53tm1Ldo
Trp53tm1Brd/Trp53tm8Xu
Trp53tm1Glo/Trp53tm4Glo
Trp53tm1Holl/Trp53tm7.1Xu
Trp53tm1Ldo/Trp53+
Trp53tm1Tyj/Trp53+
Trp53tm1Tyj/Trp53tm1.1Umol
Trp53tm1Tyj/Trp53tm2.1Tyj
Trp53tm1Tyj/Trp53tm2.1Umol
Trp53tm1Tyj/Trp53tm3.1Tyj
Trp53tm2Thst/Trp53tm2.1Thst
Trp53tm3.1Glo/Trp53+
Trp53tm3.1Tyj/Trp53+
Trp53tm7.1Xu/Trp53+
Tg(Trp53)1Srn/0
Tg(Trp53)bSrn/0
Tg(Trp53A135V)L3Ber/0
Tg(Trp53R172H)8512Jmr/0 *
Tg(Trp53R172L)4491Jmr/0
Trp53tm1Brd/Trp53tm1Brd
Tg(Nes-cre)1Kln/0  (conditional)
Trp53tm1Brd/Trp53tm1Brd
Tg(Lck-cre)1Cwi/0  (conditional)
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0  (conditional)
Trp53tm1Brn/Trp53tm1Brn  (conditional)
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)#Mam/0  (conditional)
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)105Ayn/0  (conditional)
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)#Tfln/0  (conditional)
Tg(Tek-cre)1Ywa/0
Trp53tm1Brn/Trp53tm1Brn  (conditional)
Trp53tm1Brn/Trp53tm1Brn
Tg(Wap-cre)51Nki/0  (conditional)
Trp53tm1Elee/Trp53tm1Elee
Tg(MMTV-cre)AElee/0  (conditional)
Trp53tm1Elee/Trp53tm1Elee
Tg(MMTV-cre)BElee/0  (conditional)
Trp53tm1Elee/Trp53tm1Elee
Tg(Wap-rtTA-cre)10Whl/0  (conditional)
Trp53tm6Xu/Trp53tm6Xu
Tg(Lck-cre)1Cwi/0  (conditional)
Trp53tm1Brn/Trp53+
Tg(MMTV-cre)#Tfln/0  (conditional)
Trp53tm3Tyj/Trp53+
Tg(Wap-cre)11738Mam/0  (conditional)
Tg(CMV-cre)1Cgn/0
Trp53tm4Att/Trp53+  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory